Innovations in Precision Medicine: Harnessing Cancer and Leishmaniasis Research to Discover Novel Health Therapies

The Systems Medicine Laboratory is at the vanguard of groundbreaking research in the disciplines of Leishmaniasis and Cancer. Our main goal is to discover the complex mechanisms that cause these illnesses by using cutting-edge models of infection and inflammation. To enhance biological responses and create new treatment approaches, we will use cutting-edge computational biology tools in conjunction with a systems medicine perspective.

Our Mission

Our investigation uses integrative methods and cutting-edge technology to improve health. We bridge fundamental research to clinical practice to convert our findings into effective medicines and better delivery of care.

Research Objectives

1. Leishmaniasis: Leishmaniasis is a neglected tropical disease caused by protozoan parasites. Our lab focuses on synthetic biology and computational approaches to develop new therapeutic and diagnostic strategies. Key areas of research include synthetic biology approaches, mechanobiology and cytokine signaling, computational modeling, microbiome and immune interactions, and immuno-metabolic signaling. The lab aims to bridge the gap between infection and inflammation models, advancing precision medicine in leishmaniasis and related diseases. We investigate the intricate interplay between the host immune system and Leishmania parasites. Our central goal is to design precise treatments that may successfully fight against this overlooked tropical illness by comprehending these systems.
2. Cancer: We investigate the molecular and cellular processes driving cancer development. With an eye toward new treatment targets, we investigate the tumor microenvironment and its influence on the hallmarks of cancer using inflammatory models. The vast majority of lung cancer cases (85%) are attributed to Non-Small Cell Lung Cancer (NSCLC). By combining computational biology methods with systems medicine viewpoints, the Systems Medicine Laboratory aims to achieve precision medicine. Autophagy, post-translational modifications, cytokine signaling, nanoRNAs, gene control, and sphingolipid metabolism are important areas of study. By delving into the processes that propel NSCLC growth, the group hopes to discover new treatment targets and approaches.

Computational Biology and Systems Medicine

Our lab utilizes state-of-the-art computational tools to model biological systems and predict disease outcomes. This systems medicine approach allows us to integrate large datasets and identify key regulatory networks involved in disease processes, paving the way for precision medicine.

Collaboration and Translation

Our team is committed to collaborating with other academic institutions and industry partners to expedite the clinical implementation of our results. We want to improve patient outcomes by bringing novel medicines from the lab to the clinic, and we may accomplish this through establishing these relationships.

Learn More

For more information about our research and recent publications, please visit the following resources:

Dr. Shailza Singh's Profile at NCCS

Current Publications